25. Which of the following statement is correct related to general and gene-specific transcription factors in eukaryotes?

(A) TATA-box-binding protein (TBP) binds to the minor groove of DNA, bends the consensus TATA DNA, and is required for most members of class I, II and III genes.

(B) For RNAP III, TBP is a component of the general transcription factor TFIIIC.

(C) The bZIP transcription factors dimerize through a basic domain and bind to target DNA through a leucine zipper.

(D) TFIIE and TFIIH are essential for promoter clearance and transcription elongation.

(E) The Cys2His2-zinc finger of TFIIIA is composed of an antiparallel beta-sheet followed by an alpha-helix, and the beta-sheet recognizes and binds to specific DNA sequences in the major groove.