19. Which of the following enzymes are required for nick translation of DNA replication?

(A) DNA ligase, DNA polymerase III, DNA polymerase I

(B) Primase, DNA polymerase I

(C) DNA polymerase III, DNA ligase

(D) DNA polymerase I, DNA ligase

(E) Helicase, DNA polymerase I

20. Which of the following description about eukaryotic translation is NOT TRUE?(A) eIF2-GTP brings Met-tRNA to P site of the ribosome(B) eIF2 cycle is the control of eukaryotic translation(C) 18S rRNA of small ribosome binds to Shine-Dalgarno (SD) sequence of mRNA to initiate transcription(D) Peptide bond formation is catalyzed by the peptidyltransferase which locates in 28S rRNA(E) eEF-2 is responsible for the translocation because it mimic the structure of eEF-la with aminoacyl-tRNA

21. Which of the following descriptions about Eukaryotic mRNA is NOT TRUE? (A) Eukaryotic mRNA has the 5' capping (B) Eukaryotic mRNA has poly-A tail (C) Eukaryotic mRNA is polycistronic (D) Eukaryotic mRNA does not have Shine-Dalgarno (SD) sequence (E) Eukaryotic mRNA is synthesized in the nucleus

22. photoreactivation repair_____

23. Base excision repair_____

24. Recombinational repair_____

25. Mismatch repair_____

複選題1. Which of the following statements regarding "Cell Cycle" are CORRECT? (A) Cyclin D/Cdk4 functions during M phase (B) Cyclins are destructed by proteasomes (C) Kinetochores assemble at the telomere (D) Separase, a cysteine protease, initiates sister chromatid segregation at anaphase by cleaving APC (E) Cyclin A/Cdk2 activity can be inhibited by p21 CIP

複選題2. Which of the following statements regarding "Cancer Genetics" are CORRECT? (A) Hereditary tumors usually possess loss-of-heterozygosity in proto-oncogenes (B) All the cells in a female tumor have the same inactive X chromosome, which is because that all the tumor cells are derived from a single progenitor cell (C) A gain of function mutation in Rb will bypass the restriction point controls (D) Micro-RNAs are a new class of oncogenic factors because they function to induce errors during DNA replication (E) Some viruses can via integrating into the human genome to activate the cellular proto-oncogenes and contribute to tumor formation.

複選題3. Which of the following statements regarding "Stem Cells" are CORRECT? (A) The Dolly sheep was cloned using somatic cell nuclear transfer (B) Myeloid stem cells are in the cell lineage which can give rise to T cells (C) The stem cells can be induced to divide asymmetrically in responsive to the external cue from the niche (D) Stem cells are only found in the embryonic tissues but not in the adult tissues (E) The differentiated mouse fibroblasts can be reprogrammed to pluripotent stem cells when transfected with vectors expressing KLF4, OCT4, and TERT

複選題4. Which of the following statements "Biochemical Interaction" are CORRECT? (A) Ionic bond is stronger than the Van der Waals interaction (B) Glutamine is a negatively charged amino acid (C) The sulfhydryl group in two adjacent cysteine can oxidize to form a covalent disulfide bond (D) The less of Ka (the dissociation constant) indicates a weaker binding affinity between two molecules (E) Three hydrogen bonds form between T and A in a Watson-Crick base pair interactions

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