8. Which of the following protein domains would be most likely to recognize and bind to acetylated lysine residues on nucleosomes?
(A) homeodomains
(B) zinc fingers
(C) bromodomains
(D) chromodomains

9. Cells, when infected by a DNA virus, can transcribe both stands of the viral DNA and process it into ~21 nt single stranded fragments that can be loaded into protein complexes which target viral protein encoding transcripts for degradation. Which statement below correctly characterizes this process? (A) This siRNA silencing results in a gene knock out. (B) This siRNA silencing results in a gene knock down. (C) This miRNA silencing results in a gene knock out. (D) This miRNA silencing results in a gene knock down. (E) This miRNA silencing results in reversible gene regulation

10. The Central Dogma of molecular biology states that one gene leads to one transcript and results in one protein product. Which of the following processes would refute this dogma? (A) Ordered splicing. (B) RNA editing. (C) Telomerase activity. (D) Translation start site recognition. (E) Polyadenylation of new transcripts.

11. Which of the arrows in the diagram below best represents the position and direction of leading strand DNA synthesis? The vertical bars at the center of the diagram depict the replication origin. (A) A (B) B (C) C (D) D

12. Not all mutations inside the open reading frame of a gene encoding a protein change the amino acid sequence of the protein because: (A) tRNAs carrying different amino acids can recognize the same codon (B) some codons specify more than one amino acid (C) two different codons can specify the same amino acid (D) some codons are skipped during translation (E) some codons consist of more than three nucleotides

複選題13. Eukaryotic protein synthesis: (A) proceeds in a 5' 3' direction (B) is coupled to transcription (C) always begins with a formyl-methionine (D) utilizes energy stored in the aminoacyl-tRNA (E) terminates at the sequence 5'-AAUAAA-3'

14. RNA molecules that exhibit catalytic activity are called (A) mRNAs (B) ribonucleases (C) ribosomes (D) ribozymes

15. Which of the following scientists provided definitive evidence for the chromosomal theory? (A) Mendel (B) Morgan (C) McClintock (D) Miescher (E) Avery

16. Which of the following would not be considered a mutation? (A) permanent replacement of guanine with thymine in a DAN strand (B) deletion of gene segment (C) insertion of an intron in the middle of an exon (D) permanent replacement of cytosin with adenine (E) crossing over of two gene regions during meiosis

17. A patient presents with α-thalessemia. Below is the mRNA transcribed from the patient's α-globin gene. What is the most likely result in this individual? Note: The ellipse (...) represents a continuation of the RNA beyond the sequence you are given. (A) defective transcription initiation (B) normal protein, this is a silent mutation (C) defective translation initiation (D) shorter protein, this is a nonsense mutation (E) Glycine → Serine mutation in the protein

18. All the following statements about molecular chaperones are true except (A) They play a role in the proper folding of proteins. (B) They are located in every cellular compartment. (C) They are found only in mammals. (D) They bind a wide range of proteins.

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